Certified Gastroenterology Registered Nurse Practice Exam 2025 – Comprehensive All-in-One Guide for Exam Success

The statement that Crohn's disease involves the full thickness of the bowel wall with segmental involvement is accurate because one of the hallmark characteristics of Crohn's disease is its ability to affect all layers of the gastrointestinal tract, from the mucosa to the serosa. This transmural inflammation can lead to complications such as fistulas and strictures. In addition, Crohn's disease is known for its segmental or skip lesions, meaning that the inflammation can occur in patches throughout the digestive tract, with healthy segments in between the areas of inflammation.

This pattern of involvement differentiates it from other gastrointestinal conditions like ulcerative colitis, which typically involves only the mucosal layer and has a continuous pattern of inflammation. The other statements are not representative of Crohn's disease: it does not restrict itself to the innermost layer, it is not localized solely to the rectum, and while it can lead to bowel obstructions, this is not a definitive outcome of the disease.